Your browser doesn't support javascript.
loading
Efficacy Analysis of Unrelated Umbilical Cord Blood Transplantation for the Treatment of Wiskott-Aldrich Syndrome / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1816-1821, 2018.
Artigo em Chinês | WPRIM | ID: wpr-774380
ABSTRACT
OBJECTIVE@#To explore the clinical efficacy and safety of unrelated umbilical cord blood transplantation (UCBT) for the treatment of Wiskott-Aldrich syndrome(WAS).@*METHODS@#Five pediatric patients with WAS received single UCBT were retrospectively analyzed. The median age of these male patients was 268 days (range, 3 days -695 days). Among them, 2 patients were transplanted with a 6/6 matched cord blood graft,the other 3 patients received a 5/6 matched cord blood graft. Myeloablative conditioning regimen was applied, and all patients received a combination of cyclosporine and mycophenolate mofetil for the prophylaxis of graft versus host disease (GVHD). The recovery time of neutrophils and platelets as well as chimerism after transplantation were taken as the evidence of hematopoietic reconstruction.@*RESULTS@#All the five pediatric patients had hematopoietic recovery. A median time of neutrophil cells after transplantation was at 15.8 days (range,11 days -25 days), and platelet recovery was at a median of 20.4 days(range,12 days-30 days). Chimerism data were available for 5 patients at 30 days after UCBT, 4 out of the 5 patients had full donor chimerism and only one patient had mixed chimerism. There were 2 cases with pre-engraftment syndrome, 3 cases with acute GVHD gradeⅠ-Ⅲ, 4 cases with pulmonary infection and cytomegalovirus infection, but chronic GVHD was not observed in 5 cases. Four patients were alive with a median follow-up of 12.3 months (range, 5 months-17 months), and one patient had died at 22 days after UCBT.@*CONCLUSION@#Unrelated umbilical cord blood transplantation is a safe and effective treatment method for Wiskott-Aldrich syndrome.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome de Wiskott-Aldrich / Estudos Retrospectivos / Resultado do Tratamento / Condicionamento Pré-Transplante / Transplante de Células-Tronco de Sangue do Cordão Umbilical / Doença Enxerto-Hospedeiro Tipo de estudo: Estudo observacional Limite: Humanos / Lactente / Masculino / Recém-Nascido Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2018 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome de Wiskott-Aldrich / Estudos Retrospectivos / Resultado do Tratamento / Condicionamento Pré-Transplante / Transplante de Células-Tronco de Sangue do Cordão Umbilical / Doença Enxerto-Hospedeiro Tipo de estudo: Estudo observacional Limite: Humanos / Lactente / Masculino / Recém-Nascido Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2018 Tipo de documento: Artigo