A review on muscle-specific microRNAs as the biomarker for Duchenne muscular dystrophy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1148-1152, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-775040
ABSTRACT
MicroRNA (miRNA) is a non-coding single-stranded RNA with a length of approximately 22 nucleotides and is mainly responsible for the regulation of gene expression at the post-transcriptional level. At present, miRNA have become potential biomarkers for various diseases such as tumor, leukemia, and nervous system disease. Muscle-specific microRNAs are enriched in the skeletal muscle of patients with Duchenne muscular dystrophy (DMD) and also play an important role in the pathogenesis of DMD. Creatine kinase has limited specificity in the diagnosis of DMD since its level is not significantly associated with disease severity, and therefore, it is of great clinical significance to explore whether muscle-specific microRNAs can be used as ideal biomarkers for DMD. This article reviews the research advances in this field.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biomarcadores
/
Músculo Esquelético
/
Creatina Quinase
/
Distrofia Muscular de Duchenne
/
MicroRNAs
/
Genética
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2019
Tipo de documento:
Artigo
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