Clinical features and prognosis of meconium aspiration syndrome complicated by pulmonary hemorrhage in neonates / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1059-1063, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-775056
ABSTRACT
OBJECTIVE@#To study the clinical features and prognosis of meconium aspiration syndrome (MAS) complicated by neonatal pulmonary hemorrhage (NPH) in neonates.@*METHODS@#A retrospective analysis was performed for the clinical data of 45 neonates with MAS complicated by NPH who were admitted to the hospital from December 2015 to December 2018 (observation group). Ninety neonates with MAS who were hospitalized during the same period of time and had no pulmonary hemorrhage were enrolled as the control group. The two groups were compared in terms of clinical features and prognosis.@*RESULTS@#The observation group had a significantly lower 1-minute Apgar score after birth than the control group (P<0.05). Compared with the control group, the observation group had significantly higher incidence rates of persistent pulmonary hypertension of the newborn, air leak syndrome and shock and a higher rate of use of pulmonary surfactant (P<0.05), as well as higher levels of C-reactive protein and oxygen index (OI) (P<0.01). In the early diagnosis of NPH, OI had a sensitivity of 80.0%, a specificity of 96.7%, and an area under the receiver operating characteristic curve of 0.959 (95% confidence interval 0.929-0.988, P<0.001) at the cut-off value of 10.05. For the children who were cured and discharged, the observation group had significantly longer duration of ventilation, duration of oxygen inhalation and length of hospital stay than the control group (P<0.05).@*CONCLUSIONS@#Neonates with MAS complicated by NPH tend to have a longer duration of ventilation and higher incidence rates of air leak syndrome and shock. OI may be used as an index for the early diagnosis of MAS complicated by NPH.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Surfactantes Pulmonares
/
Síndrome de Aspiração de Mecônio
/
Estudos Retrospectivos
/
Hemorragia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Humanos
/
Recém-Nascido
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2019
Tipo de documento:
Artigo
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