Clinical effect of azithromycin adjuvant therapy in children with bronchiolitis: a systematic review and Meta analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 812-819, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-775101
ABSTRACT
OBJECTIVE@#To systematically evaluate the clinical effect of azithromycin (AZM) adjuvant therapy in children with bronchiolitis.@*METHODS@#Related databases were searched for randomized controlled trials (RCTs) on AZM adjuvant therapy in children with bronchiolitis published up to February 17, 2019. RevMan 5.3 was used to perform the Meta analysis.@*RESULTS@#A total of 14 RCTs were included, with 667 children in the intervention group and 651 in the control group. The pooled effect size showed that in the children with bronchiolitis, AZM adjuvant therapy did not shorten the length of hospital stay (MD=-0.29, 95%CI -0.62 to 0.04, P=0.08) or oxygen supply time (MD=-0.33, 95%CI -0.73 to 0.07, P=0.10), while it significantly shortened the time to the relief of wheezing (MD=-1.00, 95%CI -1.72 to -0.28, P=0.007) and cough (MD=-0.48, 95%CI -0.67 to -0.29, P<0.00001). The analysis of bacterial colonization revealed that AZM therapy significantly reduced the detection rates of Streptococcus pneumoniae (OR=0.24, 95%CI 0.11-0.54, P=0.0006), Haemophilus (OR=0.28, 95%CI 0.14-0.55, P=0.0002), and Moraxella catarrhalis (OR=0.21, 95%CI 0.11-0.40, P<0.00001) in the nasopharyngeal region.@*CONCLUSIONS@#AZM adjuvant therapy can reduce the time to the relief of wheezing and cough in children with bronchiolitis, but it has no marked effect on the length of hospital stay and oxygen supply time.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bronquiolite
/
Sons Respiratórios
/
Terapia Combinada
/
Azitromicina
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Tempo de Internação
Tipo de estudo:
Ensaio Clínico Controlado
/
Revisões Sistemáticas Avaliadas
Limite:
Criança
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2019
Tipo de documento:
Artigo
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