Progress on structural biology of voltage-gated ion channels / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 25-33, 2019.
Article
em Zh
| WPRIM
| ID: wpr-775258
Biblioteca responsável:
WPRO
ABSTRACT
Ion channels mediate ion transport across membranes, and play vital roles in processes of matter exchange, energy transfer and signal transduction in living organisms. Recently, structural studies of ion channels have greatly advanced our understanding of their ion selectivity and gating mechanisms. Structural studies of voltage-gated potassium channels elucidate the structural basis for potassium selectivity and voltage-gating mechanism; structural studies of voltage-gated sodium channels reveal their slow and fast inactivation mechanisms; and structural studies of transient receptor potential (TRP) channels provide complex and diverse structures of TRP channels, and their ligand gating mechanisms. In the article we summarize recent progress on ion channel structural biology, and outlook the prospect of ion channel structural biology in the future.
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1
Índice:
WPRIM
Assunto principal:
Fisiologia
/
Ativação do Canal Iônico
/
Química
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Canais de Sódio Disparados por Voltagem
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Canais Iônicos
/
Metabolismo
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2019
Tipo de documento:
Article