Graft failure in allogeneic hematopoietic stem cell trans-plantation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 651-658, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-775265
ABSTRACT
With the progress of medical technology, the development of new drugs and the improvement of the therapeutic effect of graft-versus host disease in the last two decades, the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) have been greatly improved. However, graft failure is still a rare but serious complication of allo-HSCT. HLA incompatibility, virus infection, elderly donor, uncontrolled primary disease, damage of bone marrow hematopoietic microenvironment, ABO blood group incompatibility, T cell depletion, reduced intensity conditioning, and low nucleated cell number are all risk factors for graft failure. In recent years, with the implementation of HLA haplo-identical hematopoietic stem cell transplantation, the role of donor-specific antibodies in graft failure has attracted attention increasingly. This article reviews the recent studies involving the mechanism, risk factors and prevention measures of graft failure in allo-HSCT.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Padrões de Referência
/
Transplante Homólogo
/
Epidemiologia
/
Fatores de Risco
/
Transplante de Células-Tronco Hematopoéticas
/
Condicionamento Pré-Transplante
/
Doença Enxerto-Hospedeiro
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS