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Progress on cancer associated fibroblasts in tumor immunoregulation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 558-563, 2018.
Artigo em Chinês | WPRIM | ID: wpr-775279
ABSTRACT
Cancer associated fibroblasts (CAFs) are important components of the tumor microenvironment. Through secreting of multiple growth factors, cytokines and proteases, CAFs play a significant role in regulating the recruitment and function of various innate immune cells and adaptive immune cells in tumor microenvironment. In addition, extracellular matrix secreted by CAFs can also promote the formation of immunosuppression and hypoxia of tumor microenvironment. Here, we review the progress on CAFs in regulation of immune cells and tumor immunity.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Alergia e Imunologia / Matriz Extracelular / Microambiente Tumoral / Fibroblastos Associados a Câncer / Neoplasias Limite: Humanos Idioma: Chinês Revista: Journal of Zhejiang University. Medical sciences Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Alergia e Imunologia / Matriz Extracelular / Microambiente Tumoral / Fibroblastos Associados a Câncer / Neoplasias Limite: Humanos Idioma: Chinês Revista: Journal of Zhejiang University. Medical sciences Ano de publicação: 2018 Tipo de documento: Artigo