Roles of CCAAT enhancer binding protein α in acute myeloblastic leukemia / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 552-557, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-775280
ABSTRACT
The CCAAT enhancer binding protein α (C/EBP αp42 and p30),which encoded by CCAAT enhancer binding protein α () gene,plays a pretty crucial role in the regulation of myeloid hematopoiesis.The disorder of CEBPA gene expression is an pivotal mechanism of acute myeloid leukemia (AML). The result of uncontrolled expression of C/EBP α gene is the over-expression of p30 and the incomplete loss of p42, both of which contribute to the occurrence of AML. Restoring the expression ratio of C/EBP α such as over-expression of p42 or blocking the carcinogenic pathway of p30 seems to be important for the treatment of AML caused by such causes. In order to better guide medical decision-making, this article reviews research progress on C/EBPα in the pathogenesis of AML.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Leucemia Mieloide Aguda
/
Regulação Neoplásica da Expressão Gênica
/
Proteína alfa Estimuladora de Ligação a CCAAT
/
Genética
/
Hematopoese
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2018
Tipo de documento:
Artigo
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