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Research progress on anti-inflammatory mechanism of natural sesquiterpenoids / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3989-3999, 2018.
Artigo em Chinês | WPRIM | ID: wpr-775387
ABSTRACT
Sesquiterpenoid is a kind of compound widely distributed in nature, which has a wide range of biological activities, such as anti-inflammatory, anti-tumor and immunomodulatory activities. This paper would review the anti-inflammatory mechanism of sesquiterpenoid. The mechanism is mainly by inhibiting the activation of nuclear factor (NF-κB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor- (TNF-), prostaglandin E₂ (PGE₂), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Thereby, the production and release of inflammatory cytokines are reduced to exert anti-inflammatory effect. This review is intended to provide reference for related research.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Sesquiterpenos / Dinoprostona / Transdução de Sinais / NF-kappa B / Interleucinas / Fator de Necrose Tumoral alfa / Sistema de Sinalização das MAP Quinases / Fatores de Transcrição STAT / Anti-Inflamatórios Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Sesquiterpenos / Dinoprostona / Transdução de Sinais / NF-kappa B / Interleucinas / Fator de Necrose Tumoral alfa / Sistema de Sinalização das MAP Quinases / Fatores de Transcrição STAT / Anti-Inflamatórios Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2018 Tipo de documento: Artigo