Prognostic Significance of Bcl-2 Expression in Transitional Cell Carcinoma of the Bladder / 대한비뇨기과학회지
Korean Journal of Urology
;
: 1080-1086, 1996.
Artigo
em Coreano
| WPRIM
| ID: wpr-77554
ABSTRACT
The protein encoded by the Bcl-2 proto-oncogene has been shown to prolong cell survival by preventing programmed cell death (apoptosis). Recent work has elucidated Bcl-2 expression in many solid tumors including bladder tumor. Because there exists some controversy as to the prognostic significance of Bcl-2 in bladder cancer, we examined the cellular expression of Bcl-2 protein using immunohistochemistry in tumor samples from 89 patients with bladder cancer and determined whether expression of Bcl-2 has prognostic significance in bladder cancer. We found Positive staining for Bcl-2 (>5% positive cells) in 41 patients (40%). Bcl-2 expression was strongly correlated with tumor stage and grade (superficial vs. invasive, pO.l) and weakly correlated with progression-free survival (p In invasive tumors, Bcl-2 expression was correlated with shortened actuarial survival (p<0.025). We assessed the effect of Bcl-2 status on the response to chemotherapy or radiotherapy in 25 patients with invasive tumor. The patients with Bcl-2 positive tumors had significantly higher response rate than with Bcl-2 negative tumors (p<0.05). These results suggest that Bcl-2 protein plays an important role in tumorigenesis of bladder cancer and that Bcl-2 expression is not superior to tumor stage and grade in assessing the prognosis of patients with superficial tumors. However, Bcl-2 expression is associated with shortened actuarial survival in the patients with invasive tumor, which may be partly due to chemosensitivity or radiosensitivity in relation to the apoptotic process.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Tolerância a Radiação
/
Radioterapia
/
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Proto-Oncogenes
/
Imuno-Histoquímica
/
Carcinoma de Células de Transição
/
Sobrevivência Celular
/
Morte Celular
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
1996
Tipo de documento:
Artigo
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