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A Meta-Analysis of Efficacy and Adverse Effects of Lobaplatin and Cisplatin in the Treatment of Malignant Pleural Effusion / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 90-98, 2019.
Artigo em Chinês | WPRIM | ID: wpr-775659
ABSTRACT
BACKGROUND@#The aim of this study is to systematically evaluate the efficacy and adverse effects of Lobaplatin and Cisplatin in the treatment of malignant pleural effusion.@*METHODS@#The databases of Medline (PubMed), Embase, Web of Science, Cochrane, Wanfang, CNKI and VIP were retrieved so as to search the studies about the randomized controlled clinical trials (RCT) that compared the Lobaplatin and Cisplatin for malignant pleural effusion. The main outcome indicators include objective response rate, complete response, partial response, nephrotoxicity, chest pain, gastrointestinal reaction, myelosuppression, fever response and hepatotoxicity. Relative risk was used as the effect size, which was expressed as 95% confidence interval. The meta-analysis was performed using Stata 14.0 statistical software.@*RESULTS@#A total of 12 RCTs and 720 MPE patients were included. The results showed that the ORR (RR=1.27, 95%CI 1.15-1.40, P<0.001), CR (RR=1.39, 95%CI 1.09-1.78, P=0.007), PR (RR=1.21, 95%CI 1.02-1.42, P=0.026) in LBP thoracic perfusion chemotherapy were significantly higher than those in DDP thoracic perfusion chemotherapy. The incidence of nephrotoxicity (RR=0.31, 95%CI 0.13-0.71, P=0.005) and gastrointestinal reactions (RR=0.44, 95%CI 0.31-0.62, P<0.001) in the LBP group were significantly lower than those in DDP group.@*CONCLUSIONS@#Compared with DDP pleural perfusion chemotherapy, the ORR, CR and PR of LBP pleural perfusion chemotherapy for MPE are significantly better than DDP, and its nephrotoxicity and gastrointestinal reactions are remarkably lower than DDP.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Compostos Organoplatínicos / Ensaios Clínicos Controlados Aleatórios como Assunto / Derrame Pleural Maligno / Cisplatino / Ciclobutanos / Usos Terapêuticos / Tratamento Farmacológico / Antineoplásicos Tipo de estudo: Ensaio Clínico Controlado / Estudo de etiologia / Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Lung Cancer Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Compostos Organoplatínicos / Ensaios Clínicos Controlados Aleatórios como Assunto / Derrame Pleural Maligno / Cisplatino / Ciclobutanos / Usos Terapêuticos / Tratamento Farmacológico / Antineoplásicos Tipo de estudo: Ensaio Clínico Controlado / Estudo de etiologia / Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Lung Cancer Ano de publicação: 2019 Tipo de documento: Artigo