Advances in research on gene and cell therapy for type IV collagen related hereditary kidney diseases / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 179-182, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-775783
ABSTRACT
Type IV collagen is a component of the extracellular matrix in the basement membrane. Abnormal secretion or assembly of type IV collagen may lead to kidney lesions resulting in numerous nephropathy symptoms, e.g., Alport syndrome, thin basement membrane nephropathy, and focal segmental glomerulosclerosis. Treatment for type IV collagen-related nephropathy includes drugs, kidney transplantation, gene and cell therapy. However, drugs are not always effective, and kidney transplantation is hindered by the shortage of donors. Moreover, basement membrane nephritis often occurs after kidney transplantation. Therefore, gene and cell therapy probably is the most promising treatment for type IV collagen related nephropathies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glomerulosclerose Segmentar e Focal
/
Colágeno Tipo IV
/
Terapia Baseada em Transplante de Células e Tecidos
/
Hematúria
/
Nefrite Hereditária
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2019
Tipo de documento:
Artigo
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