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Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy--
AKT/m-TOR Pathway and Resistance to Cancer Therapy / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 63-66, 2018.
Artigo em Inglês | WPRIM | ID: wpr-776376
ABSTRACT
Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Transdução de Sinais / Biomarcadores Tumorais / Resistencia a Medicamentos Antineoplásicos / Tratamento Farmacológico / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Terapia de Alvo Molecular / Metabolismo / Métodos Limite: Animais / Humanos Idioma: Inglês Revista: Chinese Journal of Lung Cancer Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Transdução de Sinais / Biomarcadores Tumorais / Resistencia a Medicamentos Antineoplásicos / Tratamento Farmacológico / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Terapia de Alvo Molecular / Metabolismo / Métodos Limite: Animais / Humanos Idioma: Inglês Revista: Chinese Journal of Lung Cancer Ano de publicação: 2018 Tipo de documento: Artigo