Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy--
AKT/m-TOR Pathway and Resistance to Cancer Therapy / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 63-66, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-776376
ABSTRACT
Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Transdução de Sinais
/
Biomarcadores Tumorais
/
Resistencia a Medicamentos Antineoplásicos
/
Tratamento Farmacológico
/
Proteínas Proto-Oncogênicas c-akt
/
Serina-Treonina Quinases TOR
/
Terapia de Alvo Molecular
/
Metabolismo
/
Métodos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Lung Cancer
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS