Effects of aerobic exercise and glutamine on oxidative stress and expression of related factors in type 2 diabetic rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 150-154, 2019.
Article
em Zh
| WPRIM
| ID: wpr-776543
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WPRO
ABSTRACT
OBJECTIVE@#To investigate the effects of aerobic exercise and glutamine (Gln) on anti-oxidative stress and inflammatory factors in type 2 diabetes mellitus (T2MD) rats.@*METHODS@#Diabetic rat model was induced by streptozotocin (STZ). Fifty 6-week old male SD rats were randomly divided into 5 groups (n=10), including quiet control group (N), diabetes control group (D), diabetic aerobic exercise group (DE), diabetic glutamine group (DG) and diabetic aerobic exercise glutamine group (DEG). After 6 weeks, the related indicators of glucose and lipid metabolism, anti-oxidative stress and inflammatory factors in diabetic rats were detected, and the possible mechanism affecting inflammatory response were explored.@*RESULTS@#Compared with group N, the levels of serum malondialdehyde(MDA), blood glucose, total cholesterol(TC), triglyceride(TG), insulin, leptin and tumor necrosis factor-α(TNF-α) in group D were increased significantly (P<0.01). Compared with group D, serum levels of MDA, blood glucose, TC, TG, insulin, leptin and TNF-α in three intervention groups were decreased significantly, while the levels of SOD, GSH-Px and adiponectin were increased, and the combined effect was more obvious (P<0.01).@*CONCLUSION@#Both aerobic exercise and Gln can relieve the glucose and lipid metabolism and disturbance, oxidative stress injury and inflammation in diabetic rats.
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Índice:
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Assunto principal:
Farmacologia
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Condicionamento Físico Animal
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Terapêutica
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Sangue
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Glicemia
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Distribuição Aleatória
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Ratos Sprague-Dawley
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Estresse Oxidativo
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Leptina
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Diabetes Mellitus Experimental
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2019
Tipo de documento:
Article