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Protective effects of Shenmai injection on intestinal mucosal barrier function in severely scalded rats / 中国应用生理学杂志
Article em Zh | WPRIM | ID: wpr-776562
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE@#To investigate the protective effects of shen-mai injection on intestinal barrier function in the early stage of 30% 3° scald, and to provide experimental basis for the prevention and control of enterogenic infection.@*METHODS@#A total of 60 Wistar rats were randomly divided into 6 groups: normal control group (without treatment), model control group (with 30% total body surface area (TBSA) fully thickness burn on the back), hexadecadrol (5 mg/kg) group, Shenmai injection (5, 10, 15 mg/kg) groups, with 10 rats in each group. After burned by scald apparatus, rats in each group were treated with drugs immediately by intraperitoneal injection once a day. At 72 hours after burned, the levels of plasma endotoxin, diamine oxidase (DAO), tumor necrosis factor-alpha (TNF-α), interleukins-6(IL-6) in all rats were detected and the mesenteric lymph nodes, liver and spleen were homogenized to culture for bacteria. The change of secretory immunoglobulin A (sIgA) in intestinal mucosa was measured.@*RESULTS@#Compared with normal control group, bacterial translocation quantity in mesenteric lymph nodes(MLN), liver, and spleen, and the plasma levels of DAO, endotoxin, TNF-α, IL-6 and the level of sIgA in intestinal mucosa in model control group were increased significantly (P<0.01); compared with model control group, bacterial translocation quantity in MLN, liver, and spleen, and the plasma levels of DAO, endotoxin, TNF-α, IL-6 and the level of sIgA in intestinal mucosa in hexadecadrol (5 mg/kg) group and shen-mai injection (5, 10, 15 mg/kg) groups were decreased significantly (P<0.05 or P<0.01).@*CONCLUSION@#Shen-mai injection can alleviate intestinal mucosa injury caused by severe scald, and the effects are similar with those of dexamethasone, and the effect is better in the high-dose group.
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Farmacologia / Queimaduras / Medicamentos de Ervas Chinesas / Distribuição Aleatória / Ratos Wistar / Translocação Bacteriana / Combinação de Medicamentos / Mucosa Intestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Chinese Journal of Applied Physiology Ano de publicação: 2019 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Farmacologia / Queimaduras / Medicamentos de Ervas Chinesas / Distribuição Aleatória / Ratos Wistar / Translocação Bacteriana / Combinação de Medicamentos / Mucosa Intestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Chinese Journal of Applied Physiology Ano de publicação: 2019 Tipo de documento: Article