Effects of Mitochondrial Dysfunction via AMPK/PGC-1 α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 386-394, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-776594
ABSTRACT
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1 α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis, distal axonopathy and nerve demyelination in DPN. Some Chinese medicine formulae or extracts from herbs may have potential neuroprotective effects on DPN via activating AMPK/PGC-1 α pathway and improving mitochondrial function.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Transdução de Sinais
/
Fármacos Neuroprotetores
/
Usos Terapêuticos
/
Neuropatias Diabéticas
/
Tratamento Farmacológico
/
Proteínas Quinases Ativadas por AMP
/
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo
/
Medicina Tradicional Chinesa
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese journal of integrative medicine
Ano de publicação:
2019
Tipo de documento:
Artigo
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