Triptolide, A Potential Autophagy Modulator / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 233-240, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-776622
ABSTRACT
As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy. This article highlights the current information on triptolide-modulated autophagy, analyzes the possible pathways involved, and describes the crosstalk between autophagy and apoptosis modulated by triptolide, in hope of providing implications for the roles of autophagy in pharmacological effects of triptolide and expanding its novel usage as an autophagy modulator.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Fenantrenos
/
Autofagia
/
Apoptose
/
Fármacos Neuroprotetores
/
Diterpenos
/
Tratamento Farmacológico
/
Compostos de Epóxi
/
Podócitos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Chinese journal of integrative medicine
Ano de publicação:
2019
Tipo de documento:
Artigo
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