Role of Microtubule-Associated Protein in Autism Spectrum Disorder / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 1119-1126, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-777009
ABSTRACT
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication, along with repetitive and restrictive patterns of behaviors or interests. Normal brain development is crucial to behavior and cognition in adulthood. Abnormal brain development, such as synaptic and myelin dysfunction, is involved in the pathogenesis of ASD. Microtubules and microtubule-associated proteins (MAPs) are important in regulating the processes of brain development, including neuron production and synaptic formation, as well as myelination. Increasing evidence suggests that the level of MAPs are changed in autistic patients and mouse models of ASD. Here, we discuss the roles of MAPs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno Autístico
/
Comportamento Social
/
Modelos Animais de Doenças
/
Transtorno do Espectro Autista
/
Metabolismo
/
Proteínas Associadas aos Microtúbulos
/
Neurônios
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2018
Tipo de documento:
Artigo
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