AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 527-533, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-777035
ABSTRACT
Oligodendrocytes (OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYK-deficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Proteínas Tirosina Quinases
/
Diferenciação Celular
/
Células Cultivadas
/
Oligodendroglia
/
Doenças Desmielinizantes
/
Ratos Sprague-Dawley
/
Regulação da Expressão Gênica no Desenvolvimento
/
Proteína Proteolipídica de Mielina
Limite:
Animais
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS