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Effects of Ketamine on Basal Gamma Band Oscillation and Sensory Gating in Prefrontal Cortex of Awake Rats / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 457-464, 2018.
Article em En | WPRIM | ID: wpr-777043
Biblioteca responsável: WPRO
ABSTRACT
Gamma band oscillation (GBO) and sensory gating (SG) are associated with many cognitive functions. Ketamine induces deficits of GBO and SG in the prefrontal cortex (PFC). However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that (1) ketamine administration increased GBO power in the PFC in rats differently in the low- and high-dose groups; (2) auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and (3) changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power.
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Texto completo: 1 Índice: WPRIM Assunto principal: Farmacologia / Fases do Sono / Fatores de Tempo / Vigília / Estimulação Acústica / Estatística como Assunto / Análise de Variância / Ratos Sprague-Dawley / Córtex Pré-Frontal / Antagonistas de Aminoácidos Excitatórios Limite: Animals Idioma: En Revista: Neuroscience Bulletin Ano de publicação: 2018 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Farmacologia / Fases do Sono / Fatores de Tempo / Vigília / Estimulação Acústica / Estatística como Assunto / Análise de Variância / Ratos Sprague-Dawley / Córtex Pré-Frontal / Antagonistas de Aminoácidos Excitatórios Limite: Animals Idioma: En Revista: Neuroscience Bulletin Ano de publicação: 2018 Tipo de documento: Article