Modulation of drug-metabolizing enzymes and transporters under hypoxia environment / 生理学报
Acta Physiologica Sinica
;
(6): 336-342, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-777181
ABSTRACT
Drug metabolism is significantly affected under hypoxia environment with changes of pharmacokinetics, expression and function of drug-metabolizing enzymes and transporters. Studies have shown that hypoxia increases the release of a series of inflammatory cytokines which can modulate drug metabolism. Besides, both hypoxia inducible factor 1α (HIF-1α) and microRNA-mediated pathways play a role in regulating drug metabolism. This article reviewed the impact and single-factor modulating mechanisms of drug metabolism under hypoxia, and put forward the speculation and prospects of multi-factor modulating mechanisms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas de Membrana Transportadoras
/
Fisiologia
/
Preparações Farmacêuticas
/
Hipóxia Celular
/
MicroRNAs
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Hipóxia
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2019
Tipo de documento:
Artigo
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