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Nutritional status alters the mRNA expressions of galanin and its receptors in taste buds of rats / 生理学报
Acta Physiologica Sinica ; (6): 294-300, 2019.
Artigo em Chinês | WPRIM | ID: wpr-777186
ABSTRACT
The nutritional and metabolic status alters the peripheral taste perception and food intake by participating in the modulation of taste information integration. The taste receptors and neuropeptides in the taste buds are the important targets of this modulation process. To explore the effects of nutritional status on the expressions of galanin and its receptors in the taste buds, we compared the mRNA levels of galanin and its specific receptor GalR2 in the taste buds among the high-fat diet induced obese rats (HF), chronically restricted diet rats (CR) and control rats. The high-fat diet, half of chow diet, and normal chow diet were given to HF, CR and control groups for 6 weeks, respectively. The body weight and some metabolic indexes, including blood glucose, triglyceride and cholesterol levels were detected. The mRNA expressions of galanin and its receptors in taste buds were determined using real-time PCR. Results showed that compared with control rats, the body weights, levels of blood glucose and triglyceride were significantly elevated in HF rats; while the mRNA expressions of galanin and GalR2 were dramatically decreased. However, galanin mRNA expression in CR rats was increased to 2.3 times of that in control group. Considering the results obtained from our previous studies, we conclude that the behavioral changes in tasting choice of HF rats may be related to the expressions of galanin and GalR2 in the taste buds. The changes of galanin and GalR2 in taste buds are involved in the peripheral mechanism of nutritional status regulating taste perception and feeding behavior in rats.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Papilas Gustativas / Peso Corporal / RNA Mensageiro / Estado Nutricional / Galanina / Receptor Tipo 2 de Galanina / Metabolismo Limite: Animais Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Papilas Gustativas / Peso Corporal / RNA Mensageiro / Estado Nutricional / Galanina / Receptor Tipo 2 de Galanina / Metabolismo Limite: Animais Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2019 Tipo de documento: Artigo