Urinary biomarkers for chronic kidney disease: a focus on gene transcript / 生理学报
Acta Physiologica Sinica
;
(6): 644-648, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-777219
ABSTRACT
Chronic kidney disease (CKD) is becoming an alarming health burden worldwide, however, there is still lack of early biomarkers and effective treatment options. Thus, in the upcoming era of precision medicine, searching for the sensitive, non-invasive biomarkers has been the cornerstone and major challenge in the management of CKD. Urine contains rich biological information which could be an ideal source for non-invasive biomarkers of CKD. This review will discuss the recent advances in biomarker study from urine sediment, urine supernatant and urinary extracellular vesicles with special interest in gene transcript (miRNA, mRNA) biomarkers. Besides, the challenges and future directions for urinary gene transcript biomarker study will be discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Urina
/
RNA Mensageiro
/
Biomarcadores
/
MicroRNAs
/
Diagnóstico
/
Insuficiência Renal Crônica
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2018
Tipo de documento:
Artigo
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