New advances in renal mechanisms of high fructose-induced salt-sensitive hypertension / 生理学报
Acta Physiologica Sinica
;
(6): 581-590, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-777227
ABSTRACT
Fructose intake has increased dramatically over the past century and the upward trend has continued until recently. Increasing evidence suggests that the excessive intake of fructose induces salt-sensitive hypertension. While the underlying mechanism is complex, the kidney likely plays a major role. This review will highlight recent advances in the renal mechanisms of fructose-induced salt-sensitive hypertension, including (pro)renin receptor-dependent activation of intrarenal renin-angiotensin system, increased nephron Na transport activity via sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter, increased renal uric acid production, decreased renal nitric oxide production, and increased renal reactive oxygen species production, and suggest actions based on these mechanisms that have therapeutic implications.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema Renina-Angiotensina
/
Ácido Úrico
/
Pressão Sanguínea
/
Espécies Reativas de Oxigênio
/
Cloreto de Sódio na Dieta
/
Trocador 3 de Sódio-Hidrogênio
/
Frutose
/
Hipertensão
/
Rim
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2018
Tipo de documento:
Artigo
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