Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan
Environmental Health and Preventive Medicine
; : 8-8, 2019.
Article
em En
| WPRIM
| ID: wpr-777633
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND@#In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan.@*METHODS@#Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß-microglobulin and blood and urinary cadmium levels were measured.@*RESULTS@#The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß-microglobulin level higher than 10,000 μg/g cr. and a blood cadmium level higher than 6 μg/L or urinary cadmium level higher than 10 μg/g cr., respectively. Subjects who fulfilled both criteria were diagnosed with cadmium nephropathy. Six out of 57 patients (10.5% of all subjects) had cadmium nephropathy.@*CONCLUSIONS@#This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants.@*REGISTRATION NUMBER@#No. 6, date of registration: 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration: 26 December, 2013 (Akita University).
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WPRIM
Assunto principal:
Urina
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Sangue
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Cádmio
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Intoxicação por Cádmio
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Monitoramento Ambiental
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Distribuição por Sexo
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Creatinina
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Exposição Ambiental
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Poluentes Ambientais
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Hospitais
Tipo de estudo:
Diagnostic_studies
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Screening_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Environmental Health and Preventive Medicine
Ano de publicação:
2019
Tipo de documento:
Article