Current challenges to primary liver cancer research / 临床肝胆病杂志

ABSTRACT

Primary liver cancer is a common malignancy with increasing incidence and mortality. Remarkable progress has been made in the clinical research on liver cancer, but challenges to further improvement are still rigorous. This article reviews the progress and difficulties of primary liver cancer study from the following aspects molecular classification and stem cell biology, pathological and clinical diagnosis, clinical staging, surgical treatment, loco-regional treatment, molecular targeted therapy, systemic chemotherapy, management of portal vein tumor thrombus, antiviral therapy, diagnosis and treatment of intrahepatic cholangiocarcinoma, and multimodality treatment. The future strategies to further improve primary liver cancer study are also investigated.