A novel approach for treating hepatocellular carcinoma: epigenetic therapy / 临床肝胆病杂志

ABSTRACT

Recent studies have shown that the pathophysiology of hepatocellular carcinoma (HCC) involves epigenetic alterations in DNA methylation, histone modifications, and microRNAs. In this review, we describe the general characteristics of epigenetic machinery in HCC as well as the current advances in epigenetic therapy for HCC. It is pointed out that epigenetic therapy has good prospects in the treatment of HCC, but there is still a long way before clinical application.