Research progress in biomarkers of drug-induced liver injury / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 1822-1826, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-778414
ABSTRACT
Drug-induced liver injury (DILI) is a major reason for the recall of marketed drugs and the failure of clinical trials. Detection of potential liver injury remains a challenge for clinical management and preclinical drug safety studies. Currently, serum levels of alanine aminotransferase and aspartate aminotransferase are the gold standards for evaluating liver injury. However, these biomarkers are nonspecific and insensitive, and often result in false-positive results. Therefore, researchers have never stopped searching for the biomarkers of DILI with high sensitivity and specificity. This review summarizes recent research progress in the biomarkers of DILI to better predict and diagnose DILI.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Chinês
Revista:
Journal of Clinical Hepatology
Ano de publicação:
2016
Tipo de documento:
Artigo
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