Role of circulating microRNAs in development and progression of liver fibrosis / 临床肝胆病杂志

ABSTRACT

Recent studies have found that microRNAs (miRNAs) can be secreted via exosomes, stay outside the cells, and keep stable in circulating blood. Various studies have shown that the changes in circulating miRNAs are associated with different pathological states, suggesting that the circulating miRNAs can be used as potential molecular targets for the diagnosis and treament of diseases. Research has shown that miRNAs are closely associated with the development and progression of liver fibrosis. This article reviews the studies on the differences in the expression of circulating miRNAs in the course of liver fibrosis and points out that circulating microRNAs can provide a new research direction for early noninvasive diagnosis and treatment of liver fibrosis.