Immunological characteristics of tumor antigen specific T cells and their possible mechanisms in hepatocellular carcinoma / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 1220-1224, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-778472
ABSTRACT
Hepatocellular carcinoma (HCC) is a major health problem around the world and its morbidity is increasing year by year. HCC has a low rate of early diagnosis and advanced HCC has a low survival rate. Therefore, the diagnosis and treatment of HCC has attracted great attention, and tumor specific T cell immunity plays an important role in it. This article describes the immunological characteristics of seven HCC-associated antigen specific T cells, i.e., alpha fetal protein, phosphatidylinositol proteoglycan-3, NY-ESO-1, SSX-2, melanoma antigen gene A, telomerase reverse transcriptase, and HCC-associated antigen-519/target protein xklp-2, and analyzes the possible mechanisms which affect antigen specific T cell immunity from the aspects of regulatory T cells, myeloid-derived suppressor cells, antigen presenting and processing, inhibitory receptors, and CD4+T cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de rastreamento
Idioma:
Chinês
Revista:
Journal of Clinical Hepatology
Ano de publicação:
2016
Tipo de documento:
Artigo
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