Regulatory effect of interleukin-10 on natural killer cells in patients with chronic hepatitis B / 临床肝胆病杂志

ABSTRACT

At present, it is very difficult to cure chronic hepatitis B (CHB) with current therapeutic methods. Natural killer (NK) cells are an important part of innate immunity and play an important role in immune surveillance and early anti-infectious immune process. Interleukin-10 (IL-10) is a multifunctional negative regulatory factor and is involved in the biological regulation of immune cells and inflammatory cells. This article introduces the features and functions of IL-10 and NK cells, the association of CHB with IL-10 and NK cells, and the value of IL-10 and NK cells in the treatment of CHB, and points out that in CHB, IL-10 exerts a negative regulatory effect on NK cells. Further investigations are needed to confirm whether the antiviral function of NK cells can be enhanced through blocking the regulatory effect of IL-10 on NK cells, and whether liver immunopathology induced by activation of NK cells can be avoided at the same time.