Accuracy of FibroScan for diagnosis of primary liver cancer: a Meta-analysis / 临床肝胆病杂志

ABSTRACT

ObjectiveTo investigate the accuracy of liver stiffness (LS) measured by FibroScan in the diagnosis of primary liver cancer through a meta-analysis. MethodsThe databases of PubMed, Embase, CBM, CMCI, VIP, and CNKI were searched, and a manual search was performed for related journals, to collect the articles on LS measured by FibroScan in the diagnosis of primary liver cancer published from January 2003 to June 2015. QUADAS was applied for quality evaluation and data extraction, and Meta Disc 1.4 software was applied for the Meta-analysis. ResultsA total of 6 English articles which met the inclusion criteria were included. The tests for heterogeneity showed no threshold effect, but the presence of heterogeneity caused by other reasons. In the articles included, the cut-off value for LS in the diagnosis of primary liver cancer was 11-53.7 kPa, and the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, with their respective 95% confidence intervals, were 0.66(0.61-0.71), 0.78(0.76-0.79), 3.19(239-4.25), 0.45(0.30-0.66), and 8.63(4.34-17.18), respectively. The area under the summary receiver operating characteristic curve was 0.8268, and the Q index was 0.7597. ConclusionLS measured by FibroScan has good accuracy in the diagnosis of primary liver cancer, and holds promise for clinical application.