Advances in research and application of liver organoids / 临床肝胆病杂志

ABSTRACT

Liver diseases significantly affect human health. Classic research models cannot maintain hepatocyte polarity for a long time and have a different genetic background from normal human hepatocytes, which limits the research on the physiological functions of hepatocytes and the mechanisms of related diseases. The latest liver organoid technology can obtain liver organoids with partial liver structure by reprogrammed induced pluripotent stem cells or in vitro culture of liver biopsy tissue and maintain long-term proliferation and genetic stability, and therefore, it is expected to become a powerful tool for disease modelling, drug screening, and cell therapy. This article mainly reviews the research and application of liver organoids in recent years.