Significance of hepatitis B virus pregenomic RNA in the progression of chronic hepatitis B / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 2221-2223, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-778982
ABSTRACT
Hepatitis B virus (HBV) pregenomic RNA (pgRNA) is the direct transcription product of HBV covalently closed circular DNA (cccDNA) and can reflect the transcriptional activity of HBV cccDNA and the progression of chronic hepatitis B, which provides guidance for clinical treatment and prognostic prediction. Compared with other common serological markers for HBV infection, HBV pgRNA is more sensitive in reflecting HBV replication and the effect of antiviral therapy has a certain predictive value for endpoints in the stages of antiviral therapy. This article elaborates on the significance of HBV pgRNA in reflecting the changes in disease conditions with reference to the correlation of HBV pgRNA with HBcrAg and HBV cccDNA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Chinês
Revista:
Journal of Clinical Hepatology
Ano de publicação:
2018
Tipo de documento:
Artigo
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