Biological function of translationally controlled tumor protein and its role in the development and progression of hepatocellular carcinoma / 临床肝胆病杂志

ABSTRACT

Translationally controlled tumor protein (TCTP) is widely expressed in most animal and plant cells and is involved in various physiological activities. Studies have shown that liver cancer tissue has significantly higher expression of TCTP than normal tissue. This article introduces the main biological functions of TCTP, such as promoting cell growth and development, regulating cell cycle, inhibiting cell apoptosis, reducing cell stress response, and regulating inflammatory response. Besides changing cell cycle and inhibiting cell apoptosis, TCTP can also induce mitotic defects and chromosomal instability, mediate inflammatory response and hepatic fibrosis, and thus promote the development and progression of hepatocellular carcinoma(HCC). It is pointed out that TCTP might be used as a potential marker for the early diagnosis of HCC, and targeted reduction of TCTP expression might be a new method for the treatment of HCC.