Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
Experimental & Molecular Medicine
;
: 1-10, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-77907
ABSTRACT
The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic beta-catenin and then the accumulated beta-catenin is translocated into the nucleus, where it activates the transcriptional factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef), and thereby stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Tight regulation of this response involves post-translational modifications of the components of the Wnt signaling pathway. Phosphorylation, ubiquitination, and sumoylation have been shown to affect the half-life of beta-catenin and the transcriptional activity of Tcf/Lef. The precise spatio-temporal patterns of these multiple modifications determine the driving force of various cellular responses.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ligação Proteica
/
Sítios de Ligação
/
Transdução de Sinais
/
Transativadores
/
Processamento de Proteína Pós-Traducional
/
Regulação da Expressão Gênica
/
Proteínas Wnt
/
Beta Catenina
/
Fatores de Transcrição TCF
/
Modelos Biológicos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS