The relationship between the serum concentration of VEGF and the prognosis of lung cancer / 대한내과학회지
Korean Journal of Medicine
; : 643-648, 2002.
Article
em Ko
| WPRIM
| ID: wpr-77936
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and vascular permeability. Increased serum VEGF concentrations (sVEGF) have been reported in various types of human cancer. In the current study, we assessed sVEGF to investigate the relationship between the sVEGF level and the prognosis of patients with lung cancer. METHODS: sVEGF was measured by enzyme-linked immunosorbent assay (ELISA) in 86 patients with lung cancer. Patients were divided into two groups according to 686 pg/mL of mean sVEGF (Low sVEGF group: sVEGFor=686 pg/mL, n=28). We analyzed the association of sVEGF according to the pathologic types and clinical staging, and compared the survival rates in two groups. RESULTS: There was no significant difference of sVEGF among the stages and pathologic types of lung cancer. And no difference was observed between overall survival rates of both groups regard to sVEGF (p=0.86). CONCLUSION: These results suggest that sVEGF may not be a good marker for prognosis of lung cancer, especially in the advanced cases.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Prognóstico
/
Permeabilidade Capilar
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Ensaio de Imunoadsorção Enzimática
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Taxa de Sobrevida
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Fator A de Crescimento do Endotélio Vascular
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Pulmão
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Neoplasias Pulmonares
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Medicine
Ano de publicação:
2002
Tipo de documento:
Article