A serial of Mannich bases with anti-leukemia activity / 药学学报

ABSTRACT

Thirty-three compounds were designed and synthesized directly from three-component, one-pot condensation of 1-(4-methylphenyl)ethanone and aromatic amines with some aromatic aldehydes. The chemical structures of the Mannich bases were confirmed by 1H NMR, IR and MS. The screening results of bioactivity indicated that all of these title compounds possessed the inhibitory activity at the concentration of 1×10-4 mol·L-1. Among them, the compound TM33 displayed the strongest bioactivity with the inhibition percentage of 60.3% against P338 cancer cell line at the concentration of 1×10-8 mol·L-1, and the value of the half maximal inhibitory concentration (IC50) was as low as 0.45 nmol·L-1. This study suggests a new type of potential anti-leukemia molecules.