Bromodomain and extraterminal proteins-a novel class of therapeutic targets in epigenetics / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1209-1215, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-779714
ABSTRACT
Bromodomain and extraterminal (BET) proteins are a class of proteins that can interpret epigenetic codes and play an important role in regulating gene transcription through identifying and binding acetylated histones or non-histones proteins. The BET inhibitors have emerged with good therapeutic effects in preclinical disease models such as cancer and inflammation. Some of them have entered clinical studies, demonstrating that there is considerable prospect for drug development with BET as a potential therapeutic target. This review briefly describes the structures and functions of the BET proteins, the BET inhibitors in various diseases, as well as molecular mechanisms involved.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2017
Tipo de documento:
Artigo
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