Efficacy and Safety of Carfilzomib in the Treatment of Multiple Myeloma:A Systematic Evaluation / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1887-1893, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-781523
ABSTRACT
OBJECTIVE@#To evaluate the efficacy and safety of carfilzomib in the treatment of multiple myeloma (MM).@*METHODS@#Computer was used to search PubMed, EMbase, Cochrane library and MEDLINE databases for carfilzomib treatment of MM. Clinical features and results were extracted and meta-analysis was performed using Stata12.0 software.@*RESULTS@#Twelve eligible Phase I/II, II and III clinical trials of carfilzomib were extracted and 2 487 MM patients involved in evaluable. The summary analysis showed that the rate of complete response (CR) of carfilzomib treatment was 28%, the rate of ≥very good partial response (VGPR) was 73%, and the rate of overall response rate (0RR) was 93%; the 1-year progression-free survival (PFS) rate of MM patients was 93%, the 2-year PFS rate was 85%, and the 3-year PFS rate was 74%. Three randomized controlled trials showed a significant improvement in ORR [OR=1.644, 95% CI=(1.056, 2.560) ] (P<0.05) and clinical benefit rate (CBR) in MM patients [OR=1.595, 95%) CI=(1.044, 2.435) ] (P<0.05). Compared with the control group, the OR of cardiotoxicity (P<0.05) was significantly increased, while that of peripheral neuropathy (P>0.05) was not significantly changed.@*CONCLUSION@#Compared with traditional treatments, carfilzomib significantly improves survival in the patients with multiple myeloma without increasing the incidence of peripheral neuropathy, but the incidence of cardiotoxicity seems higher.
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligopeptídeos
/
Indução de Remissão
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Mieloma Múltiplo
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2019
Tipo de documento:
Artigo
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