Efficacy of a Paclitaxel-Eluting Nitinol Stent on the Inhibition of Pseudointimal Hyperplasia in a Transjugular Intrahepatic Portosystemic Shunt: An Experimental Study in a Swine Model
Journal of the Korean Radiological Society
;
: 225-232, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-78253
ABSTRACT
PURPOSE:
To evaluate the efficacy of a paclitaxel-eluting nitinol stent on the inhibition of pseudointimal hyperplasia in a transjugular intrahepatic portosystemic shunt. MATERIALS ANDMETHODS:
Twelve pigs were used in this study. Two types of 10-mm diameter and 60-mm long nitinol stents were made for a transjugular intrahepatic portosystemic shunt by coating them with a polyurethane solution, with and without paclitaxel. Each transjugular intrahepatic portosystemic shunt was created successfully in the 12 swine with 7 paclitaxel-eluting stents and 5 polyurethane stents. Five swine in each group were followed-up for 14 days due to the death of 2 swine given the paclitaxel-eluting stents. The proliferation of the pseudointima was evaluated on both follow-up portograms and histopathology examinations. The mean maximum pseudointimal hyperplasia is expressed as the percentage of the stent radius.RESULTS:
On the portograms, all the transjugular intrahepatic portosystemic shunts using the paclitaxel-eluting stents maintained patency despite there being a complete occlusion of the polyurethane stents in all the animals. The histopathology analysis revealed the mean maximum pseudointimal hyperplasia to be 25% and 76% in the paclitaxel-eluting and control stents, respectively.CONCLUSION:
A transjugular intrahepatic portosystemic shunt with a paclitaxel-eluting nitinol stent appears to significantly inhibit the formation of pseudointimal hyperplasia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Poliuretanos
/
Rádio (Anatomia)
/
Suínos
/
Derivação Portossistêmica Cirúrgica
/
Stents
/
Seguimentos
/
Paclitaxel
/
Hiperplasia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of the Korean Radiological Society
Ano de publicação:
2007
Tipo de documento:
Artigo
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