An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 108-116, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-78353
ABSTRACT
PURPOSE:
The genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of JAK3 contributes to the development of lung cancer. This study investigated whether polymorphisms at the promoter region of the JAK3 gene are associated with the risk of lung cancer in the Korean population. MATERIALS ANDMETHODS:
A total of 819 subjects, including 409 lung cancer patients and 410 healthy controls were recruited. The SNaPshot assay and polymerase chain reaction-restriction fragment length polymorphism analysis were used, and logistic regression analyses were performed to characterize the association between polymorphisms of JAK3 and lung cancer risk.RESULTS:
Three polymorphisms (-672 G>A, +64 A>G and +227 G>A) of JAK3 were analyzed for large-scale genotyping (n=819). Statistical analyses revealed that polymorphisms and haplotypes in the JAK3 gene were not significantly associated with lung cancer.CONCLUSION:
JAK3 gene was not significantly associated with the risk of lung cancer in the Korean population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Haplótipos
/
Proteínas Tirosina Quinases
/
Modelos Logísticos
/
Regiões Promotoras Genéticas
/
Janus Quinases
/
Janus Quinase 3
/
Coreia (Geográfico)
/
Pulmão
/
Neoplasias Pulmonares
Tipo de estudo:
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2011
Tipo de documento:
Artigo
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