Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women
The Korean Journal of Internal Medicine
;
: 285-293, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-78395
ABSTRACT
BACKGROUND/AIMS:
The objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status.METHODS:
The study included 4,125 consecutive Korean subjects (30-79 years of age). Subjects who had a medical history of diabetes, hypertension, dyslipidemia, other cardiovascular disorders, or hormone replacement therapy were excluded. The women were subdivided into two groups according to their menopausal status.RESULTS:
Analysis of premenopausal women showed no significant differences in the homeostasis model of assessment-insulin resistance (HOMA-IR) index between the two groups in terms of gallstone disease. The associations between the occurrence of gallbladder stones and age, obesity, abdominal obesity, hyperinsulinemia, and high HOMA-IR index were statistically significant in the analysis with postmenopausal women. In a multiple logistic regression analysis, low high density lipoprotein-cholesterol was an independent predictor of gallbladder stone formation in premenopausal women. However, the multiple logistic regression analysis also showed that age and HOMA-IR were significantly associated with gallbladder stone formation in postmenopausal women. In an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group.CONCLUSIONS:
Insulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência à Insulina
/
Cálculos Biliares
/
Distribuição de Qui-Quadrado
/
Modelos Logísticos
/
Razão de Chances
/
Inquéritos e Questionários
/
Fatores de Risco
/
Fatores Etários
/
Pós-Menopausa
/
Medição de Risco
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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