Expression of TGF-betaand IGF-I during osseointegration of titanium implant
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
;
: 123-130, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-784616
ABSTRACT
osteoblast cell level during bone-implant integration are still largely unknown. The objective of this study was to examine expression patterns of TGF-beta and IGF-I related genes during bone-implant integration. Titanium implants with machined surface were placed into 8 rabbit tibias. At 3rd, 7th, 14th, 28th day after implantation, the expression pattern of TGF-beta and IGF-I genes in bone with or without implant was examined using reverse transcriptase-polymerase chain reaction (RT-PCR). At the same time, histomorphometric analysis was evaluated, respectively. The bone-to-implant contacts (BIC) of experimental groups were 5.2%, 6.2%, 6.6%, 24.6% at 3rd, 7th, 14th, 28th day. This indicated that newly formed bone increased at the implant surface in bone marrow space after implantation. The expressions of TGF-beta and IGF-I were higher in implantation groups than untreated control groups during all experimental days.The increased expression of TGF-beta and IGF-I genes may be associated with the increased bone-toimplant contact. This result provided the evidence for existing biologic differences in tissue response after implantation and helped us to understand molecular biologic processes in tissue-implant integration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoblastos
/
Tíbia
/
Titânio
/
Medula Óssea
/
Fator de Crescimento Insulin-Like I
/
Osseointegração
/
Fator de Crescimento Transformador beta
Idioma:
Coreano
Revista:
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Ano de publicação:
2005
Tipo de documento:
Artigo
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