A histological study on several implants for augmentation rhinoplasty in mouse calvarium

ABSTRACT

PURPOSE: This study was aimed to histologically evaluate Silicone(R), Gore-tex(R), AlloDerm(R), and Medpor(R) implants for augmentation rhinoplasty after graft in the subperiosteum of mural calvarium respectively.MATERIALS AND METHOD: Twenty four male ICR mice were used. Silicone(R), Gore-tex(R), AlloDerm(R), and Medpor(R) were grafted respectively in the subperiosteum of frontal bone. Animals were sacrificed at 1 week, 4 week and 8 week after graft. Histological observation was performed after HandE staining.RESULTS: All groups were healed without any extrusion of implant materials and inflammatory cell infiltration. In Silicone group, Silicone(R) was well enclosed by thin fibrous tissue at 1 week, which became thicker and stable at 4 weeks and 8 weeks. And there was no destruction or resorption of Silicone(R) In Gore-tex group, there was no destruction or resorption of Gore-tex(R). Thin fibrous tissue and cell infiltration from peripheral tissue were observed at 1 week, 4 weeks and 8 weeks. In AlloDerm group, AlloDerm(R) was enclosed by fibrous tissue. Cell infiltration was observed at 1 week, 4 weeks and 8 weeks. In Medpor group, there was no inflammation, destruction or resorption of Medpor(R) and it was contacted directly to the bone without interposition of fibrous tissue. Porous area was filled by bone or soft tissue.CONCLUSION: These results suggest that Gore-tex(R), AlloDerm(R), and Medpor(R) graft are more stable than Silicone(R) graft and that Silicone(R), Gore-tex(R), AlloDerm(R) are appropriate for graft on nasal tip and Medpor(R) is appropriate for graft on nasal dorsum.