Osteomyelitis Treated with Antibiotic Impregnated Polymethyl Methacrylate
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
;
: 396-401, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-785249
ABSTRACT
osteomyelitis is an infection and inflammation of the bone or bone marrow, causing ischemia in bone marrow due to lack of blood, nutrients, and oxygen supply to the bone marrow, eventually leading to necrosis of bone marrow. A current method for treatment of chronic osteomyelitis is administration of systemic antibiotics followed by removal of the infected bone and tissues. Because infected tissue of chronic osteomyelitis is surrounded by avascular necrotic bone, supply of blood and antibiotics to the infected area is diminished. For effective treatment, high plasma concentrations of antibiotics should be provided for a prolonged period. However, long term high serum level of antibiotics may result in undesirable adverse effects. For delivery of a sufficient concentration of antibiotic to the infected area while avoiding the adverse effect, implantation of a local antibiotic delivery system is suggested. One of the implantation systems that has been utilized is antibiotic impregnated polymethyl methacrylate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteomielite
/
Oxigênio
/
Plasma
/
Medula Óssea
/
Sistemas de Liberação de Medicamentos
/
Polimetil Metacrilato
/
Inflamação
/
Isquemia
/
Mandíbula
/
Antibacterianos
Idioma:
Inglês
Revista:
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Ano de publicação:
2013
Tipo de documento:
Artigo
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