Chromosomal Deletion in 7q31.2-31.32 Involving Ca2⁺-Dependent Activator Protein for Secretion Gene in a Patient with Cerebellar Ataxia: a Case Report
Brain & Neurorehabilitation
;
: 9-2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-785547
ABSTRACT
We present a 33-year-old male patient with cerebellar ataxia. He was first considered to have a psychiatric conversion disorder but finally found to have chromosomal deletion in 7q31.2-31.32 involving Ca2⁺-dependent activator protein for secretion (CADPS) gene. When a targeted gene sequencing using next-generation sequencing panel and chromosomal microarray analysis were performed, an 8.6 Mb deletion within chromosome 7q31.2-31.32 was discovered. Deletion of CADPS gene in the 7q31.2-31.32 was suggested as the causative factor of cerebellar ataxia. Functional levels evaluated by Berg balance scale and modified Barthel index were improved via comprehensive rehabilitation including balance training and a dopamine agonist medication. To the best of our knowledge, this is the first report of chromosomal deletion in 7q31.2-31.32 including CADPS gene detected in patients with cerebellar ataxia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Reabilitação
/
Ataxia Cerebelar
/
Agonistas de Dopamina
/
Transtorno Conversivo
/
Transtornos Cromossômicos
/
Análise em Microsséries
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Brain & Neurorehabilitation
Ano de publicação:
2020
Tipo de documento:
Artigo
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