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Predictors of poor prognosis in patients with heat stroke
Article em En | WPRIM | ID: wpr-785627
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE: The predictors of poor prognosis in heat stroke (HS) remain unknown. This study investigated the predictive factors of poor prognosis in patients with HS.METHODS: Data were obtained and analyzed from the health records of patients diagnosed with heat illness at Ajou university hospital between January 2008 and December 2017. Univariate and multivariate analyses were performed to identify the independent predictors of poor prognosis.RESULTS: Thirty-six patients (median age, 54.5 years; 33 men) were included in the study. Poor prognosis was identified in 27.8% of the study population (10 patients). The levels of S100B protein, troponin I, creatinine, alanine aminotransferase, and serum lactate were statistically significant in the univariate analysis. Multiple regression analysis revealed that poor prognosis was significantly associated with an increased S100B protein level (odds ratio, 177.37; 95% confidence interval, 2.59 to 12,143.80; P=0.016). The S100B protein cut-off level for predicting poor prognosis was 0.610 μg/L (area under the curve, 0.906; 95% confidence interval, 0.00 to 1.00), with 86% sensitivity and 86% specificity.CONCLUSION: An increased S100B protein level on emergency department admission is an independent prognostic factor of poor prognosis in patients with HS. Elevation of the S100B protein level represents a potential target for specific and prompt therapies in these patients.
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Texto completo: 1 Índice: WPRIM Assunto principal: Prognóstico / Biomarcadores / Análise Multivariada / Sensibilidade e Especificidade / Golpe de Calor / Ácido Láctico / Troponina I / Creatinina / Alanina Transaminase / Serviço Hospitalar de Emergência Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Clinical and Experimental Emergency Medicine Ano de publicação: 2019 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Prognóstico / Biomarcadores / Análise Multivariada / Sensibilidade e Especificidade / Golpe de Calor / Ácido Láctico / Troponina I / Creatinina / Alanina Transaminase / Serviço Hospitalar de Emergência Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Clinical and Experimental Emergency Medicine Ano de publicação: 2019 Tipo de documento: Article