The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults
Diabetes & Metabolism Journal
;
: 867-878, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-785704
ABSTRACT
BACKGROUND:
Thyroid disease and metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to investigate the correlation between thyroid hormones and obesity sub-phenotypes using nationwide data from Korea, a country known to be iodine replete.METHODS:
This study was based on data obtained from the sixth Korea National Health and Nutrition Examination Survey, administered from 2013 to 2015. A total of 13,873 participants aged ≥19 years were included, and classified into four groups metabolically healthy non-obesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO), and metabolically unhealthy obesity (MUO) by body fat on the basis of body mass index and metabolic health.RESULTS:
At baseline, serum free thyroxine (fT4) values were significantly higher in the MHNO phenotype (MHNO, 1.27±0.01 ng/dL; MHO, 1.25±0.01 ng/dL; MUNO, 1.24±0.01 ng/dL; MUO, 1.24±0.01 ng/dL, P<0.001) in total study population. However, this significant association no longer remained after adjustment for age, urine iodine concentration, and smoking (P=0.085). After adjustment for confounders, statistically significant association was observed between lower thyroid stimulating hormone (TSH) and MHNO phenotype (P=0.044). In men participants (not women), higher fT4 values were significantly associated with MHNO phenotype (P<0.001). However, no significant association was observed between thyroid function (TSH or fT4) and obesity phenotypes in groups classified by age (cutoff age of 55 years).CONCLUSION:
Although there was a difference by age and sex, we found that the decrease of TSH and the increase of fT4 values were associated with MHNO.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Fumaça
/
Doenças da Glândula Tireoide
/
Glândula Tireoide
/
Hormônios Tireóideos
/
Tiroxina
/
Tireotropina
/
Doenças Cardiovasculares
/
Fumar
/
Índice de Massa Corporal
Limite:
Adulto
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2019
Tipo de documento:
Artigo
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