Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression
Genomics & Informatics
;
: 36-2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-785805
ABSTRACT
The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), which are transcribed but not translated into functional proteins, contribute to cancer development. Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oncogenes
/
RNA
/
Biomarcadores
/
Incidência
/
Mortalidade
/
MicroRNAs
/
Proliferação de Células
/
RNA Longo não Codificante
/
Carcinogênese
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2019
Tipo de documento:
Artigo
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